Article No
AP8430a
STEP / PTPN5 Antibody
STEP / PTPN5 Antibody (N-Term)
Antibodies Primary
Specifications
| MW | 63538 |
| NCBI Number | NP_001035059.1;NP_001265165.1;NP_001265167.1;NP_001265168.1;NP_008837.1;NP_116170.3 |
| Accession Number | P54829 |
| Application | WB |
| Article No | AP8430a |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | RB00604 |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | STEP / PTPN5 Antibody (N-Term) |
| Recommended Dilution | 1:1000 |
| Supplier | Abgent |
| Entrez Gene ID | 84867 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Isotype | IgG |
| Keywords | Primary Antibodies;Neuroscience;Signal Transduction |
| Notes | STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90% identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons. |
| Alias Names | Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, Striatum-enriched protein-tyrosine phosphatase, STEP, PTPN5 |
| Product Type | Antibodies Primary |
| Research area | Neuroscience |
| Size | 400 µl |
| Source / Host | rabbit |
| Species Reactivity | human, mouse |
| Substrate / Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Technical Specifications | This STEP / PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5. |
| Product Page Updated | 2023-11-23T14:38:54.086Z |
