Article No
ASB-5MT2VV-0.5
NCBI Number | 16407 |
Application | FC, IHC |
Article No | ASB-5MT2VV-0.5 |
Biosite Brand | Biosite |
Country Availability | all |
Clone | 2E7 |
Clone Type | monoclonal |
Concentration | 0.5 mg/mL |
Conjugation | FITC |
Description | Hamster Anti-Mouse CD103-FITC |
Supplier | Nordic Biosite |
Format | Liquid |
Immunogen | C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL) |
Isotype | IgG |
Notes | CD103 is a member of the integrin series of adhesion molecules. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis, and periphery. In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. The 2E7 monoclonal antibody exhibits antigen immunoprecipitation patterns similar if not identical to the rat anti-mouse CD103 monoclonal antibody M290. 2E7 is reported to have signal-inducing activity in a redirected lysis assay and to costimulate IEL and CD8+ lymph node cells in conjunction with anti-TCR in vitro which runs counter to the usual inhibition of CTL by anti-integrins. This costimulatory activity is also shared by the monoclonal antibody M290. The property of costimulation is not unique to the mouse since the combination of anti-human alpha IEL plus anti-TCR will produce similar proliferation in human cells with the exception that CD8+ cells are not stimulated. |
Alias Names | Integrin αIEL, αE integrin, ITGAE |
Previous Article No | ASB-181002, ASB-5MT2VV-0.5 |
Product Type | Antibodies Primary |
Shipping Information | Ambient Temperature |
Size | 0.5 mg |
Source / Host | hamster |
Species Reactivity | mouse |
Storage | 2-8°C |
Substrate / Buffer | Phosphate buffered saline containing < 0.1% sodium azide |
Swiss-Prot No | Q60677 |
Product Page Updated | 2024-01-11T10:51:07.446Z |
Volume | 1.0 mL |