Article No
Ab00803-10.6
Botulinum neurotoxin type A
Anti-Botulinum neurotoxin type A [CR1]
Antibodies Primary
Specifications
| Accession Number | P10845 |
| Additional Information | This is a recombinant monoclonal antibody. |
| Application | Neutralization, FC |
| Article No | Ab00803-10.6 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | CR1 |
| Clone Type | recombinant |
| Conjugation | Unconjugated |
| Description | Anti-Botulinum neurotoxin type A [CR1] |
| Supplier | Absolute Antibody |
| Format | Purified |
| Isotype | Fab fragment |
| Notes | CR1 was produced by a yeast gene diversity library used to increase the affinitiy of scFv AR2 for BoNT/A2, while maintinaing high affinity binding to BoNT/A2. AR2 was generated after multiple rounds of affinity maturation of the humanized C25, which itself was created by CDR-grafting from the parental murine C25. Murine C25 was prepared by constructing a scFv phage display library from mice immunized with recombinant BoNT/A binding domain (Hc). |
| Alias Names | BoNT/A; BoNT; Botulinum neurotoxin; Bontoxilysin-A; Bontoxilysin A; BOTOX |
| Product Type | Antibodies Primary |
| Purification | Purified |
| Research area | Neuroscience |
| Shipping Information | Wet Ice |
| Size | 100 µg |
| Source / Host | human |
| Species Reactivity | bacteria |
| Storage | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Substrate / Buffer | PBS with 0.02% Proclin 300. |
| Technical Specifications | This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| UniProt Number | P10845 |
| Product Page Updated | 2024-03-25T11:22:07.969Z |
