Article No
BPS-27335
Specifications
| CAS No | 1268524-71-5 |
| MW | 457.0 kDa |
| Additional Information | (-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM. |
| Article No | BPS-27335 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | (-)-JQ1 |
| Supplier | BPS Bioscience |
| Notes | (-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM. |
| Molecular Formula | C23H25ClN4O2S |
| Alias Names | (R)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate |
| Product Type | Chemicals & Biochemicals |
| Shipping Information | room temp (domestic), gel packs international |
| Size | 25 mg |
| Solubility | Soluble in DMSO or ethanol at 100 mM |
| Storage | Store at or below -80°C. Stable for less than 6 months when stored as directed. |
| Technical Specifications | (-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule_x000D_ bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1_x000D_ competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin,_x000D_ which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell_x000D_ lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to_x000D_ significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and_x000D_ IC50 of 10,000 nM. |
| Product Page Updated | 2024-01-09T13:23:45.900Z |
