Article No
BPS-40019
ALK2 (ACVR1), GST-tag Recombinant
ALK2 (ACVR1), GST-tag Recombinant
Proteins & Peptides
Specifications
| MW | 67 kDa |
| Accession Number | NM_001105 |
| Additional Information | ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFβRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells (1). Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues (2). |
| Article No | BPS-40019 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | ALK2 (ACVR1), GST-tag Recombinant |
| Supplier | BPS Bioscience |
| Entrez Gene ID | 90 |
| Format | Aqueous buffer solution |
| Gene Symbol | ACVR1 |
| Notes | Recombinant human activin receptor-like kinase 2, or ALK2 (a.a. 147-end), with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system. The gene accession number is NM_001105. |
| Alias Names | ActRIA, ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI, Haspin-like |
| Product Type | Proteins & Peptides |
| Purity | ≥75% |
| Shipping Information | -80°C (dry ice) |
| Size | 10 µg |
| Source / Host | insect |
| Species Reactivity | human |
| Storage | At least 6 months at -80°C. |
| Substrate / Buffer | 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol. |
| Technical Specifications | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| UniProt Number | Q04771 |
| Product Page Updated | 2024-01-09T13:23:45.900Z |
