ARE reporter cell line (Nrf2 antioxidant pathway)

ARE reporter cell line (Nrf2 antioxidant pathway)

Article No



2 vials

Shipping Information




Additional Information Avoid freeze/thaw cycles
Article No BPS-60513
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, RU
Components Each vial contains ~2 X 10<sup>6</sup> cells in 1 ml of 10% DMSO.
Description ARE reporter cell line (Nrf2 antioxidant pathway)
Supplier BPS Bioscience
Entrez Gene ID 4780
Additional Information License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. BPS does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact sales@bpsbioscience.com for details. Publications using this cell line should reference BPS Bioscience, Inc., San Diego.
Gene Symbol NFE2L2
Notes The ARE Reporter - Hep G2 cell line is designed to monitor Nrf2 antioxidant response pathway. The cell contains a firefly luciferase gene under the control of ARE (antioxidant response element) stably integrated into Hep G2 cells.
Alias Names ARE cell line, Nrf2 reporter, Nrf
Product Type Cells
Protocol See data sheet for detailed culturing and assay protocol.
References 1. Lee, JM et. al. (2004) An important role of Nrf2-ARE pathway in the cellular_x000D_ defense mechanism. J Biochem Mol Biol. 37(2): 139-143.<br>2. Dinkova-Kostova, AT et.al. (2002) Direct evidence that sulfhydryl groups of_x000D_ Keap1 are the sensors regulating induction of phase 2 enzymes that protect_x000D_ against carcinogens and oxidants. Proc Natl Acad Sci U S A. 99(18): 11908-11913.
Research Area Cell Signaling
Shipping Information DRY ICE
Size 2 vials
Storage Liquid Nitrogen
Technical Specifications • Monitor Nrf2 antioxidant response pathway activity.<br>• Screen for activators or inhibitors of the Nrf2 antioxidant response pathway.
UniProt Number Q16236
Product Page Updated 2021-01-05T12:59:29.990Z

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