Article No
BPS-79023
14-3-3 alpha/beta Protein, His-tag (Human) Recombinant
14-3-3 alpha/beta Protein, His-tag (Human) Recombinant
Proteins & Peptides
Specifications
| MW | 32 kDa |
| Accession Number | NM_003404 |
| Additional Information | 14-3-3 alpha/beta is a member of the highly conserved 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins (1). 14-3-3 alpha/beta protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. 14-3-3-alpha/beta interacts with the TSC1-TSC2 dimer (2). The interaction required phosphorylation of TSC2 at Ser1210. Binding of 14-3-3-alpha/beta to TSC2 did not alter the interaction between TSC1 and TSC2, but it reduced the ability of the complex to inhibit phosphorylation of ribosomal protein S6 kinase impairing the ability of the complex to inhibit cell growth. |
| Application | WB |
| Article No | BPS-79023 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | 14-3-3 alpha/beta Protein, His-tag (Human) Recombinant |
| Supplier | BPS Bioscience |
| Entrez Gene ID | 7529 |
| Format | Aqueous buffer solution |
| Gene Symbol | YWHAB |
| Notes | Human 14-3-3 alpha/beta Protein, GenBank Accession No. NM_003404, full length, with C-terminal His tag, expressed in an E. coli expression system. MW = 32 kDa. |
| Alias Names | 14-3-3 alpha/beta, YWHAB, HS1, GW128, KCIP-1 |
| Product Type | Proteins & Peptides |
| Shipping Information | -80°C (dry ice) |
| Size | 20 µg |
| Species Reactivity | human |
| Storage | Store product at -80°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Substrate / Buffer | 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol |
| Technical Specifications | Western Blot |
| UniProt Number | P31946 |
| Product Page Updated | 2024-01-09T13:23:45.900Z |
