Enzymes

79367-2+1903:19

NEW
79367-2+1903:19

Article No

BPS-79345

Size

50 ug

Shipping Information

DRY ICE

Documentation

Specifications

MW 94 kDa
Accession Number NM_006301
Additional Information Recombinant Human DLK, also known as MAP3K12, MUK, and ZPK. Genbank Accession #NM_006301, a.a. 1-520, with an N-terminal GST-tag, MW = 61 kDa, expressed in Sf9 cells via a baculovirus expression system.
Article No BPS-79345
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, RU
Description 79367-2+1903:19
Supplier BPS Bioscience
Notes Recombinant Human DLK, also known as MAP3K12, MUK, and ZPK. Genbank Accession #NM_006301, a.a. 1-520, with an N-terminal GST-tag, MW = 61 kDa, expressed in Sf9 cells via a baculovirus expression system.
Alias Names MAP3K12; MUK; ZPK; ZPKP1; MEKK12; MAP3K12
Product Type Enzymes
Purity ≥75%
References 1. Hirai, S., et al., Oncogene 2011;12:641-650._x000D_ _x000D_ 2. Ferron, S., et al., Nature. 2011;475:381-385._x000D_
Shipping Information DRY ICE
Size 50 ug
Storage -80°C
Substrate / Buffer 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 10mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Technical Specifications DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun (1). Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis (2).
Product Page Updated 2021-01-05T12:59:29.990Z

Shipping info

The delivery time for this item is approximately 5-8 business days. 
If other deviations occur, this will be noted on the order confirmation or communicated via email.
Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.