AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)

AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)

Article No



2 x 500 ul

Shipping Information




Article No BPS-79823
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, RU
Description AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)
Supplier BPS Bioscience
Notes The stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) family of proteins includes mitogen-activated protein kinases (MAPKs) that are activated by stress, inflammatory cytokines, mitogens, oncogenes, and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK/JNK pathway, MAP Kinase Kinases phosphorylate and activate JNKs. The activated JNKs translocate to the nucleus where they phosphorylate and activate transcription factors such as c-Jun. c-Jun then binds to the activator protein-1 (AP1) response element and induces AP1 transcription. The AP1 Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by AP1 response element located upstream of the minimal TATA promoter. After transduction, activation of the JNK signaling pathway and AP1 mediated activity in the target cells can be monitored by measuring the luciferase activity.
Product Type Cells
Shipping Information DRY ICE
Size 2 x 500 ul
Storage -80°C
Product Page Updated 2021-01-05T12:59:29.990Z

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