The CD5 antigen is a transmembrane glycoprotein which is expressed on the most mature human T-cells and expression level of CD5 will be increased during T-cell maturation. CD5 is also expressed in a small subset of normal human B-cells as well. CD5 is expressed in most T-cell lymphomas and leukemias and negative expression of the CD5 in T-cell lymphoma indicates a worse prognosis. In B-cell lymphomas eg. small lymphocytic lymphoma, small-cell lymphoma (CD20+), and mantle cell lymphoma are typically CD5 positive and marginal zone lymphoma and follicular lymphoma, are CD5 negative.
suitable for IHC
Source / Host
Store at 4℃
Substrate / Buffer
TRIS with 0.03% sodium azide, pH7,2
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