PAX5

Article No BSH-4007-100
Product Type Antibodies Primary
Application IHC
Format Concentrate
Size 100 µl

Specifications

Country Availability all
BioSite Brand Optibodies
Clone BSR59
Clone Type monoclonal
Control Tissue Appendix, tonsil
Description Anti-PAX5, rabbit monoclonal - Optibodies
Supplier Nordic BioSite
CE/IVD true
Notes This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Alias Names BSAP
Protocol suitable for IHC-P
Source / Host rabbit
Species Reactivity human
Storage Store at 4℃
Substrate / Buffer TRIS with 0.03% sodium azide, pH7,2
Technical Specifications Control: Appendix, tonsil
UniProt Number Q02548
Product Page Updated 2019-02-20T14:36:52.701Z

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CE certified

Source/Host:

rabbit rabbit

Species reactivity:

human human

Product insert:

Suggested protocols:

IHC-P

IHC-P