Antibodies Primary

EpCAM

NEW
Anti-EPCAM, mouse monoclonal - Optibodies

Article No

BSH-7402-1

Application

IHC

Species Reactivity

human

Size

1 ml

Clone

BS14

Source / Host

mouse

Specifications

Application IHC
Article No BSH-7402-1
BioSite Brand Optibodies
Country Availability all
Clone BS14
Clone Type monoclonal
Control Tissue Control Tissues: Kidney, appendix, liver
Description Anti-EPCAM, mouse monoclonal - Optibodies
Recommended Dilution IHC-P (1:100 - 1:400)
Supplier Nordic BioSite
Format Concentrate
Notes This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.Tissue specificity: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas. EPCAM:Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium. This cell surface, glycosylated 40kD protein is highly expressed in the bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin.
Alias Names Epithelial cell-cell adhesion molecule
Product Type Antibodies Primary
Protocol suitable for IHC-P
Size 1 ml
Source / Host mouse
Species Reactivity human
Storage Store at 4℃
Substrate / Buffer TRIS with 0.03% sodium azide, pH7,2
Technical Specifications Control Tissues: Kidney, appendix, liver
UniProt Number P16422
Product Page Updated 2021-08-03T14:43:49.162Z

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