|Alias Names||MRXSYP, SYP, Synaptophysin (p38), Optibodies, Optibody|
|Description||Anti-SYP, mouse monoclonal|
|Notes||Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.|
|Source / Host||mouse|
|Species Reactivity||human, rat|
|Substrate / Buffer||TRIS with 0.03% sodium azide, pH7,2|
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