EpCAM

EpCAM

Article No BSH-7402-100
Product Type Antibodies Primary
Application IHC-P
Format Concentrate, Optibodies
Size 100 µl

Specifications

Clone BS14
Description Anti-EPCAM, mouse monoclonal - Optibodies
Supplier Nordic BioSite
Notes This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.Tissue specificity: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas. EPCAM:Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium. This cell surface, glycosylated 40kD protein is highly expressed in the bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin.
Alias Names Epithelial cell-cell adhesion molecule
Source / Host mouse
Species Reactivity human, rat, pig/porcine, sheep/ovine, dog/canine
Storage Store at 4℃
Substrate / Buffer TRIS with 0.03% sodium azide, pH7,2
Technical Specifications Control Tissues: Kidney, appendix, liver

Shipping info

The delivery time for this item is approximately 5-8 business days. Due to the upcoming holiday period, a few extra days may be added to the general delivery time. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.

Source/Host:

mouse mouse

Species reactivity:

human,rat,pig/porcine,sheep/ovine,dog/canine human rat