Article No
BT-CM0DYO-100
Specifications
| MW | ~ 32kDa |
| Application | WB, IHC, IF, IP, ChIP |
| Article No | BT-CM0DYO-100 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Conjugation | Unconjugated |
| Description | E2F6 |
| Supplier | Nordic Biosite |
| Immunogen | Recombinant full length Human E2F6. |
| Notes | The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcriptional regulators including E2F-2, E2F-3, E2F-4, E2F-5 and E2F-6, each of which forms heterodimers with a second protein, DP-1, forming an “active” E2F transcriptional regulatory complex. |
| Alias Names | Transcription factor E2F6; E2F-6; E2F6 |
| Product Type | Antibodies Primary |
| Protocol | WB: 1:500~1:2000 IHC/IF: 1:50~1:200 IP/CHIP: 1:50~1:200 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Size | 100ul |
| Source / Host | rabbit |
| Species Reactivity | human, mouse |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Substrate / Buffer | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Swiss-Prot No | O75461 |
| Product Page Updated | 2024-01-24T15:22:36.575Z |
