Article No
CHI-HF-200B7H4-C050
B7-H4 (human) (rec.)
B7-H4 (human) (rec.)
Proteins & Peptides
Specifications
| MW | ~50kDa (SDS-PAGE) |
| Accession Number | NP_078902.2 |
| Article No | CHI-HF-200B7H4-C050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | B7-H4 (human) (rec.) |
| Supplier | Adipogen Life Sciences |
| Endotoxin | <1EU/mg protein (LAL test; Lonza). |
| Format | Powder |
| Notes | B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.|Protein. The extracellular domain of human B7-H4 (aa 29-258). Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. |
| Alias Names | V-set Domain-containing T Cell Activation Inhibitor 1; VTCN1; B7h.5; Immune Costimulatory Protein B7-H4; T Cell Costimulatory Molecule B7x; Protein B7S1 |
| Product Type | Proteins & Peptides |
| Purity | >95% |
| Research area | Immunology |
| Sequence | The extracellular domain of human B7-H4 (aa 29-258). |
| Shipping Information | BLUE ICE |
| Size | 50 ug |
| Source / Host | human |
| Stability | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Lyophilized from 0.2µm-filtered solution in PBS. |
| Technical Specifications | Protein. The extracellular domain of human B7-H4 (aa 29-258). Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production, and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production, and generation of alloreactive cytotoxic T-cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. |
| UniProt Number | NP_078902.2 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
