Article No
CSB-PA001499LA01HU-100
Specifications
| Application | ELISA, IF, IHC, WB |
| Article No | CSB-PA001499LA01HU-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | AIM2 Antibody |
| Supplier | Cusabio |
| Entrez Gene ID | 9447 |
| Gene Symbol | AIM2 |
| Immunogen | Recombinant Human Interferon-inducible protein AIM2 protein (81-326AA) |
| Isotype | IgG |
| Notes | Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. |
| Product Type | Antibodies Primary |
| Purification | Protein G Purified |
| Shipping Information | BLUE ICE |
| Size | 100ug |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | -80°C |
| UniProt Number | O14862 |
| Product Page Updated | 2024-01-24T13:11:22.259Z |
