Article No
CSB-RA578819A0HU-50
PIK3CA Recombinant
PIK3CA Recombinant Monoclonal Antibody
Antibodies Primary
Specifications
| Application | ELISA, IF, WB |
| Article No | CSB-RA578819A0HU-50 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 10E5 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | PIK3CA Recombinant Monoclonal Antibody |
| Recommended Dilution | IF 1:20-1:200, WB 1:500-1:5000 |
| Supplier | Cusabio |
| Entrez Gene ID | 5290 |
| Gene Symbol | PIK3CA |
| Immunogen | A synthesized peptide derived from human PI 3 Kinase catalytic subunit alpha |
| Isotype | IgG |
| Notes | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). |
| Product Type | Antibodies Primary |
| Purification | Affinity Purified |
| Shipping Information | BLUE ICE |
| Size | 50ul |
| Source / Host | rabbit |
| Species Reactivity | human, mouse |
| Storage | -80°C |
| UniProt Number | P42336 |
| Product Page Updated | 2024-01-24T14:15:14.857Z |
