Article No
D086-3
Application | ICC, IHC, IP, WB |
Article No | D086-3 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 23-4 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Anti-ASC (TMS1) (Human) mAb |
Supplier | MBL |
Immunogen | TritonX-100 insoluble fraction of HL-60 cells were treated with retinoic acid |
Isotype | IgG1 |
Notes | ASC (apoptosis-associated speck-like protein containing a CARD (caspase recruitment domain)) is a 22 kDa soluble protein, located in the cytosol of HL-60 cells. In apoptotic HL-60 cells, it is able to visualized as a speck, forming an insoluble aggregate. The C-terminal domain of this protein contains a CARD, suggesting that ASC may have proapoptotic activity in HL-60 cells. Recent data have indicated that ASC plays a role of adaptor protein linking various PAAD (Pyrin, AIM, ASC, and death domain-like) family proteins to pathways involved in NF-κB and procaspase-1 activation. |
Product Type | Antibodies Primary |
Research Area | Cell Death |
Shipping Information | 4°C |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human |
Stability | 1 year |
Storage | -20°C |
Substrate / Buffer | 100 μg IgG in a 100 μl volume of PBS containing 50% glycerol, pH 7.2. Contains nopreservatices. |
Technical Specifications | ASC (apoptosis-associated speck-like protein containing a CARD (caspase recruitment domain)) is a 22 kDa soluble protein, located in the cytosol of HL-60 cells. In apoptotic HL-60 cells, it is able to visualized as a speck, forming an insoluble aggregate. The C-terminal domain of this protein contains a CARD, suggesting that ASC may have proapoptotic activity in HL-60 cells. Recent data have indicated that ASC plays a role of adaptor protein linking various PAAD (Pyrin, AIM, ASC, and death domain-like) family proteins to pathways involved in NF-κB and procaspase-1 activation. |
Product Page Updated | 2023-12-29T16:20:16.638Z |