This item can unfortunately not be purchased via our website. Please send an email to info@nordicbiosite.com, and we will handle your order directly.
Anti-CD274 (PD-L1) (Human) mAb-Biotin
Anti-CD274 (PD-L1) (Human) mAb-Biotin
Antibodies Primary
On Request
Specifications
| Application | FC |
| Article No | D092-6 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | MIH3 |
| Clone Type | monoclonal |
| Concentration | 20 μg/ml |
| Conjugation | Biotin |
| Description | Anti-CD274 (PD-L1) (Human) mAb-Biotin |
| Supplier | MBL |
| Immunogen | L cells were transfected with full-length human PD-L1 |
| Isotype | IgG1 |
| Notes | Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN- GM-CSF and IL-10 from the T cells were enhanced. |
| Product Type | Antibodies Primary |
| Research area | Cell Death |
| Shipping Information | 4°C |
| Size | 1 mL |
| Source / Host | mouse |
| Species Reactivity | human |
| Stability | 1 year |
| Storage | 4°C |
| Substrate / Buffer | 20 ug/mL in PBS/1% BSA/0.09% sodium azide |
| Technical Specifications | Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunoglobulin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN- GM-CSF and IL-10 from the T cells were enhanced. |
| Product Page Updated | 2024-01-10T15:49:33.450Z |
