Article No
D132-5
Application | FC |
Article No | D132-5 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | J110 |
Clone Type | monoclonal |
Conjugation | PE |
Description | Anti-CD279 (PD-1) (Human) mAb-PE |
Supplier | MBL |
Immunogen | Fusion protein of human PD-1-Fc |
Isotype | IgG1 |
Notes | Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells. |
Product Type | Antibodies Primary |
Research Area | Cell Death |
Shipping Information | 4°C |
Size | 50 Tests |
Source / Host | mouse |
Species Reactivity | human |
Stability | 1 year |
Storage | 4°C |
Substrate / Buffer | 50 tests in 1 mL volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain. |
Technical Specifications | Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells. |
Product Page Updated | 2023-12-29T16:20:16.638Z |