Article No
D147-3
Anti-Abi-1 (Abl interactor 1) (Human) mAb
Anti-Abi-1 (Abl interactor 1) (Human) mAb
Antibodies Primary
Specifications
| Application | IHC, IP, WB |
| Article No | D147-3 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 1B9 |
| Clone Type | monoclonal |
| Concentration | 1 mg/mL |
| Conjugation | Unconjugated |
| Description | Anti-Abi-1 (Abl interactor 1) (Human) mAb |
| Supplier | MBL |
| Immunogen | Recombinant human Abi-1 was expressed in Escherichia coli |
| Isotype | IgG1 |
| Notes | Abl interactor (Abi) proteins are c-Abl-binding proteins that bind to both the Src homology 3 (SH3) domain and the C-terminal proline-rich regions of Abl kinase through dual SH3-PXXP interactions. Two highly related genes, abi-1 and abi-2, were cloned. In addition to the interaction with Abl kinase, Abi proteins also interact with other signaling molecules. Recently, it has been reported that Abi-1 dramatically promoted c-Abl-mediated tyrosine (Tyr296) phosphorylation of Mena [mammalian homologue of Drosophila Enabled (Ena)] by interacting with both proteins. |
| Product Type | Antibodies Primary |
| Shipping Information | 4°C |
| Size | 100 µl |
| Source / Host | mouse |
| Species Reactivity | human, mouse, hamster, rat |
| Stability | 3 years |
| Storage | -20°C |
| Substrate / Buffer | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained. |
| Technical Specifications | Abl interactor (Abi) proteins are c-Abl-binding proteins that bind to both the Src homology 3 (SH3) domain and the C-terminal proline-rich regions of Abl kinase through dual SH3-PXXP interactions. Two highly related genes, abi-1 and abi-2, were cloned. In addition to the interaction with Abl kinase, Abi proteins also interact with other signaling molecules. Recently, it has been reported that Abi-1 dramatically promoted c-Abl-mediated tyrosine (Tyr296) phosphorylation of Mena [mammalian homologue of Drosophila Enabled (Ena)] by interacting with both proteins. |
| Product Page Updated | 2023-12-29T16:20:16.638Z |
