Article No
D281-6
Anti-CD61 (GPIIIa) (Human) mAb-Biotin
Anti-CD61 (GPIIIa) (Human) mAb-Biotin
Antibodies Primary
Specifications
| Application | FC |
| Article No | D281-6 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | T74 |
| Clone Type | monoclonal |
| Conjugation | Biotin |
| Description | Anti-CD61 (GPIIIa) (Human) mAb-Biotin |
| Supplier | MBL |
| Immunogen | Human thrombocyte |
| Isotype | IgG1 k |
| Notes | Glycoprotein IIIa, a β3 (CD61) subunit of integrin αIIbβ3 (CD41/CD61), acts as a fibrinogen receptor on the platelet surface. A mouse monoclonal antibody, T74, recognizes human β3 (CD61) subunit and inhibits platelet aggregation induced by several agonists such as collagen, ADP, and thrombin. T74 inhibits clot-retraction mediated by platelets or αvβ3-expressing cells when induced by thrombin. Western-blot analysis is not possible. T74 fails to bind to platelets from patients with Glanzmann’s thrombasthenia. |
| Alias Names | ITGB3, integrin subunit beta 3, GP3A |
| Product Type | Antibodies Primary |
| Shipping Information | 4°C |
| Size | 50 µL |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| Substrate / Buffer | 1 mg/mL in PBS/1% BSA/0.1% ProClin 150 |
| Technical Specifications | Glycoprotein IIIa, a β3 (CD61) subunit of integrin αIIbβ3 (CD41/CD61), acts as a fibrinogen receptor on the platelet surface. A mouse monoclonal antibody, T74, recognizes human β3 (CD61) subunit and inhibits platelet aggregation induced by several agonists such as collagen, ADP, and thrombin. T74 inhibits clot-retraction mediated by platelets or αvβ3-expressing cells when induced by thrombin. Western-blot analysis is not possible. T74 fails to bind to platelets from patients with Glanzmann’s thrombasthenia. |
| Product Page Updated | 2023-12-29T16:20:16.638Z |
