Article No
GTX02089
Specifications
| Application | WB |
| Article No | GTX02089 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 10 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | CD162 antibody [10] |
| Supplier | GeneTex |
| Entrez Gene ID | 6404 |
| Gene Symbol | SELPLG |
| Immunogen | Recombinant Human PSGL-1 / CD162 / SELPLG protein |
| Isotype | IgG1 |
| Notes | This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] |
| Product Type | Antibodies Primary |
| Protocol | WB: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Protein A Purified |
| Size | 100µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C, -80°C |
| UniProt Number | Q14242 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
