Article No
GTX26241
Specifications
| Application | Inhibition, Neutralization |
| Article No | GTX26241 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Concentration | 0.20 mg/ml |
| Conjugation | Unconjugated |
| Description | ANP32A peptide |
| Supplier | GeneTex |
| Entrez Gene ID | 8125 |
| Gene Symbol | ANP32A |
| Notes | Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after release from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activates procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-mediated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-mediated cell transformation. |
| Product Type | Proteins & Peptides |
| Protocol | The peptide is used for blocking the activity of PHAP I antibody (cat. no GTX25992). It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C. |
| Size | 50µg |
| Storage | -20°C |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
