Article No
GTX83864
Application | FC, IP, WB |
Article No | GTX83864 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | 3F12 |
Clone Type | monoclonal |
Concentration | 1.01 mg/ml |
Conjugation | Unconjugated |
Description | PLK1 antibody [3F12] |
Supplier | GeneTex |
Entrez Gene ID | 5347 |
Gene Symbol | PLK1 |
Immunogen | Full-length protein expressed in 293T cell transfected with human PLK1 expression vector |
Isotype | IgG1 |
Notes | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. |
Product Type | Antibodies Primary |
Protocol | WB: 1:1000-1:2000. FACS: 1:100. IP: 2ug/500ul. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
Purification | Affinity Purified |
Size | 100µl |
Source / Host | mouse |
Species Reactivity | human, mouse |
Storage | 4°C, -80°C |
UniProt Number | P53350 |
Product Page Updated | 2024-01-03T10:31:47.950Z |