Article No
JAI-MHN-020P
anti-4-Hydroxy-2-nonenal [4-HNE], mAb (HNEJ-2)
anti-4-Hydroxy-2-nonenal [4-HNE], mAb (HNEJ-2)
Antibodies Primary
Specifications
| Application | IHC, WB |
| Article No | JAI-MHN-020P |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | HNEJ-2 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | anti-4-Hydroxy-2-nonenal [4-HNE], mAb (HNEJ-2) |
| Supplier | Adipogen Life Sciences |
| Format | Powder |
| Immunogen | 4-Hydroxy-2-nonenal (4-HNE) modified keyhole limpet hemocyanin. |
| Isotype | IgG1 k |
| Notes | Monoclonal Antibody. Recognizes 4-HNE-lysine, 4-HNE-histidine and 4-HNE cysteine adduct. Has much higher affinity for the 4-HNE-histidine adduct than 4-HNE-lysine or 4-HNE cysteine adduct. Shows almost negligible reactivity with proteins that were treated with other aldehydes, such as 2-nonenal, 2-hexenal, 1-hexanal, 4-hydroxy-2-hexenal, formaldehyde, or glutaraldehyde. Lyophilized. Contains 50mM Tris-buffered saline (TBS). Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation.|Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation. |
| Product Type | Antibodies Primary |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 20 µg |
| Source / Host | mouse |
| Species Reactivity | human, multi species |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Lyophilized. Contains 50mM Tris-buffered saline (TBS). |
| Technical Specifications | Monoclonal Antibody. Recognizes 4-HNE-lysine, 4-HNE-histidine and 4-HNE cysteine adduct. Has much higher affinity for the 4-HNE-histidine adduct than 4-HNE-lysine or 4-HNE cysteine adduct. Shows almost negligible reactivity with proteins that were treated with other aldehydes, such as 2-nonenal, 2-hexenal, 1-hexanal, 4-hydroxy-2-hexenal, formaldehyde, or glutaraldehyde. Lyophilized. Contains 50mM Tris-buffered saline (TBS). Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
