Antibodies Primary

Anti-MICA/B (Human) mAb

NEW
Anti-MICA/B (Human) mAb

Article No

K0219-3

Application

ELISA, FC, WB

Species Reactivity

human

Size

100 µg

Clone

BAMO1

Source / Host

mouse

Shipping Information

4°C

Product insert

Suggested protocols

Specifications

Application ELISA, FC, WB
Article No K0219-3
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, FO, GL, RU
Clone BAMO1
Clone Type monoclonal
Concentration 1 mg/mL
Description Anti-MICA/B (Human) mAb
Supplier MBL International Corp.
Immunogen P815 cells were transfected with MICA * 01, MICA * 04, MICB * 02
Isotype IgG1 k
Notes MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, γδT cells and CD8+αβT cells. Recognition of MICA and MICB by NKG2D is involved in tumor surveillance, immune responses to viral infections and autoimmune diseases. MICA and MICB are transmembrane glycoproteins that are distantly related to the MIC proteins, and they possess three extra-cellular Ig-like domains. And thus, MICA and MICB are closely related but are functionally indistinguishable. MICA and MICB molecules are highly glycosylated, and are detected as a smear band ranging from 65-75 kDa. It is reported that MICA and MICB are highly expressed in variant tumor cells, whereas normal cells express little. Tumor cells have been shown to shed and release MIC molecules from the cell surface. Therefore determination of soluble MIC (sMIC) levels provides valuable information for cancer staging, andsMIC in serum seems to be an indicator for systemic manifestation of malignancy rather than for local tumor extent.
Product Type Antibodies Primary
References 1) Spreu, J., et al., J. Immunol. 177, 3143-3149 (2006) 2) Armeanu, S., et al., Cancer Res. 65, 6321-6329 (2005) 3) Wu, J. D., et al., J. Clin. Invest. 114, 560-568 (2004) 4) Welte, S. A., et al., Eur. J. Immunol. 33, 194-203 (2003) 5) Salih, H. R., et al., Blood 102, 1389-1396 (2003) 6) Salih, H. R., et al., J. Immunol. 169, 4098-4102 (2002) Clone BAMO1 is used in these references.
Shipping Information 4°C
Size 100 µg
Source / Host mouse
Species Reactivity human
Stability 1 year
Storage -20°C
Substrate / Buffer 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Technical Specifications MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, γδT cells and CD8+αβT cells. Recognition of MICA and MICB by NKG2D is involved in tumor surveillance, immune responses to viral infections and autoimmune diseases. MICA and MICB are transmembrane glycoproteins that are distantly related to the MIC proteins, and they possess three extra-cellular Ig-like domains. And thus, MICA and MICB are closely related but are functionally indistinguishable. MICA and MICB molecules are highly glycosylated, and are detected as a smear band ranging from 65-75 kDa. It is reported that MICA and MICB are highly expressed in variant tumor cells, whereas normal cells express little. Tumor cells have been shown to shed and release MIC molecules from the cell surface. Therefore determination of soluble MIC (sMIC) levels provides valuable information for cancer staging, andsMIC in serum seems to be an indicator for systemic manifestation of malignancy rather than for local tumor extent.
Product Page Updated 2020-06-10T09:56:05.519Z

Shipping info

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