Article No
LS-B8738-50
Complement C4c
Complement C4c antibody LS-B8738 is an unconjugated mouse monoclonal antibody to human Complement C4c. Validated for ELISA, Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Antibodies Primary
Specifications
| Application | ELISA, FC, IHC, WB |
| Article No | LS-B8738-50 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 10-12 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Complement C4c antibody LS-B8738 is an unconjugated mouse monoclonal antibody to human Complement C4c. Validated for ELISA, Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues. |
| Recommended Dilution | IHC-P (10 ug/ml) |
| Supplier | LifeSpan Biosciences |
| Immunogen | Purified human C4c. |
| Isotype | IgG1 |
| Notes | Complement C4c antibody LS-B8738 is an unconjugated mouse monoclonal antibody to human Complement C4c. Validated for ELISA, Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues. |
| Product Type | Antibodies Primary |
| Protocol | ELISA: Binds both C4c and C4 and so is not suitable for all ELISA applications. |
| Purification | Protein A Purified |
| Shipping Information | RT |
| Size | 50 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | BBS, 0.09% Sodium Azide |
| Technical Specifications | Recognizes complement component 4c (C4c). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonization and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kD) and alpha 3 (25 kD) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma. Binds both C4c and C4 and so is not suitable for all ELISA applications. |
| Product Page Updated | 2024-04-12T06:35:05.844Z |
