Article No
LS-C188265-0.25
CLEC7A / Dectin 1
Dectin 1 antibody LS-C188265 is an unconjugated rat monoclonal antibody to mouse Dectin 1 (CLEC7A). Validated for Flow, IHC and IP.
Antibodies Primary
Specifications
| NCBI Number | 64581 |
| Application | FC, IHC, IP |
| Article No | LS-C188265-0.25 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 2A11 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Dectin 1 antibody LS-C188265 is an unconjugated rat monoclonal antibody to mouse Dectin 1 (CLEC7A). Validated for Flow, IHC and IP. |
| Recommended Dilution | FC (1:10 - 1:50) |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 64581 |
| Gene Symbol | CLEC7A |
| Immunogen | Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1. |
| Isotype | IgG2b |
| Notes | Dectin 1 antibody LS-C188265 is an unconjugated rat monoclonal antibody to mouse Dectin 1 (CLEC7A). Validated for Flow, IHC and IP. |
| Alias Names | CLEC7A, BGR, CANDF4, CLECSF12, Dectin-1, DC-associated C-type lectin 1, DECTIN1, HDectin-1, Beta-glucan receptor, Lectin-like receptor 1, CD369 |
| Product Type | Antibodies Primary |
| Protocol | The epitope recognized by 2A11 is sensitive to H202 treatment, therefore quenching with 0.3% H202 should be performed after incubation with the primary antibody. The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Acetone fixation should be used for frozen sections. |
| Purification | Protein G Purified |
| Shipping Information | RT |
| Size | 0.25 mg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | 4°C |
| Substrate / Buffer | PBS, 0.09% Sodium Azide |
| Technical Specifications | Recognizes murine beta-glucan receptor, also known as Dectin-1. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macrophages via the protein tyrosine kinase known as Syk. Inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version is recommended for functional studies. |
| Product Page Updated | 2024-04-12T06:35:05.844Z |
