Article No
LS-C43741-0.5
CD71 / Transferrin Receptor
Transferrin Receptor antibody LS-C43741 is an unconjugated mouse monoclonal antibody to rat Transferrin Receptor (CD71). Validated for Flow, IF, IHC and WB.
Antibodies Primary
Specifications
| NCBI Number | 7037 |
| Application | FC, IF, IHC, WB |
| Article No | LS-C43741-0.5 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | OX-26 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Transferrin Receptor antibody LS-C43741 is an unconjugated mouse monoclonal antibody to rat Transferrin Receptor (CD71). Validated for Flow, IF, IHC and WB. |
| Recommended Dilution | FC (1:10 - 1:100) |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 7037 |
| Gene Symbol | TFRC |
| Immunogen | PHA activated rat lymphocytes |
| Isotype | IgG2a |
| Notes | Transferrin Receptor antibody LS-C43741 is an unconjugated mouse monoclonal antibody to rat Transferrin Receptor (CD71). Validated for Flow, IF, IHC and WB. |
| Alias Names | TFRC, CD71, TFR1, TRFR, TFR, TR, CD71 antigen, p90, T9, Transferrin receptor, Transferrin receptor protein 1 |
| Product Type | Antibodies Primary |
| Protocol | The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request. |
| Purification | Protein G Purified |
| Shipping Information | RT |
| Size | 0.5 mg |
| Source / Host | mouse |
| Species Reactivity | rat |
| Storage | -20°C |
| Substrate / Buffer | PBS |
| Technical Specifications | Recognizes rat CD71, also known as transferrin receptor, a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Clone 0X-26 also binds to a number of non-dividing normal tissues. The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialized proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimer's€™s, Parkinson's, Huntington's and Multiple Sclerosis. Is reported as suitable for use in immunoelectron microscopy. OX-26 detects a band of ~95kD in Western blotting under reducing conditions and ~195kD under non-reducing conditions reflecting it's homodimeric structure. |
| Product Page Updated | 2024-04-12T09:20:06.597Z |
