Article No
LS-C44979-0.1
Complement C5
Complement C5 antibody LS-C44979 is an unconjugated mouse monoclonal antibody to human Complement C5 (N-Terminus). Validated for ELISA and WB.
Antibodies Primary
Specifications
| NCBI Number | 727 |
| Application | ELISA, WB |
| Article No | LS-C44979-0.1 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 046-10.2.2 (10-04) |
| Clone Type | monoclonal |
| Concentration | 1.08 mg/ml |
| Conjugation | Unconjugated |
| Description | Complement C5 antibody LS-C44979 is an unconjugated mouse monoclonal antibody to human Complement C5 (N-Terminus). Validated for ELISA and WB. |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 727 |
| Gene Symbol | C5 |
| Immunogen | Purified human C5. |
| Isotype | IgG1 |
| Notes | Complement C5 antibody LS-C44979 is an unconjugated mouse monoclonal antibody to human Complement C5 (N-Terminus). Validated for ELISA and WB. |
| Alias Names | C5, Anaphylatoxin C5a analog, CPAMD4, Complement C5, Complement component 5 |
| Product Type | Antibodies Primary |
| Purification | Protein A Purified |
| Shipping Information | RT |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | BBS, 0.1% Sodium Azide |
| Technical Specifications | Recognizes secreted complement component 5 (C5), a 190kD serine protease present in blood serum. It is composed of an 115kD disulphide linked alpha-chain and a 75 kD beta-chain. In addition to its role in complement, C5 is thought to be associated with inflammation, stimulating tumor necrosis factor alpha, interferon gamma mediated suppression of IL10 and IL12 production. C5 is activated via either the classical or the alternative complement pathway, by proteolytic cleavage of C5a from the N-terminal of the alpha-chain, by C5 convertase. C5a is an anaphylatoxin which mediates local inflammation. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. It also stimulates chemotaxis of neutrophils, eosinophils, basophils and monocytes towards the site of inflammation. The remaining fragment, C5b, initiates the assembly of the membrane attack complex. In hemolysis inhibition studies it was found that Will block C5 hemolytic activity. Removal of sodium azide is recommended prior to use in functional assays. XXX XXX recommend the use of EUQOO3 for this purpose. |
| Product Page Updated | 2024-04-12T09:51:03.289Z |
