Article No
M045-3
Application | WB |
Article No | M045-3 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 2C4 |
Clone Type | monoclonal |
Concentration | 1 mg/mL |
Conjugation | Unconjugated |
Description | Anti-Phospho-RB (Ser780) (Human) mAb |
Supplier | MBL |
Immunogen | synthetic human phospho-RB (Ser780) peptide, TRPPTLS (PO3) PIPHIP, which corresponding to amino acids 774-786 of human pR |
Isotype | IgG1 |
Notes | Cyclin-dependent kinases (Cdks) play important roles in the regulation of the cell cycle. RB protein (pRB) is phosphorylated by cyclin D-Cdk4/Cdk6 and cyclin A/cyclin E-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of pRB. pRB undergo phosphorylationm and attendant functional inactivation, the cell proceed into late G1. Cyclin D-Cdk4 specifically phosphorylates Ser780 in pRB, while cyclin E-Cdk2 and cyclin A-Cdk2 does not. |
Product Type | Antibodies Primary |
Shipping Information | 4°C |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human |
Stability | 1 year |
Storage | -20°C |
Substrate / Buffer | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
Technical Specifications | Cyclin-dependent kinases (Cdks) play important roles in the regulation of the cell cycle. RB protein (pRB) is phosphorylated by cyclin D-Cdk4/Cdk6 and cyclin A/cyclin E-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of pRB. pRB undergo phosphorylationm and attendant functional inactivation, the cell proceed into late G1. Cyclin D-Cdk4 specifically phosphorylates Ser780 in pRB, while cyclin E-Cdk2 and cyclin A-Cdk2 does not. |
Product Page Updated | 2023-12-29T16:20:16.638Z |