Antibodies Primary

Anti-BID (Human) mAb

NEW
Anti-BID (Human) mAb

Article No

M072-3

Application

WB

Species Reactivity

human

Size

100 µg

Clone

5C9

Source / Host

mouse

Shipping Information

4°C

Product insert

Suggested protocols

Specifications

Application WB
Article No M072-3
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, FO, GL, RU
Clone 5C9
Clone Type monoclonal
Concentration 1 mg/mL
Description Anti-BID (Human) mAb
Supplier MBL International Corp.
Immunogen Recombinant human Bid (61-118 a.a. end N)
Isotype IgG1
Notes Apoptosis is a major form of cell death characterized by several morphological features that include chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathway that leads to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-10 (also known as Mch4, FLICE2 and ICE-LAP4) is a ~58 kDa protein. This caspase acts upstream of the apoptosis induced cascade. Once this caspase is activated by certain apoptotic stimuli, this protein may be responsible for the activation of the other caspases such as caspase-3, -4, -7, -8, and -9. This antibody was made against human-originated immunogen, and detects human caspase-10 specifically.
Product Type Antibodies Primary
References 1) Thiery, J., et al., J. Immunol. 174, 871-878 (2005) 2) Uddin, S., et al., Clin. Cancer Res. 11, 3102-3108 (2005) 3) Baumann, R., et al., FASEB J. 17, 2221-2230 (2003) 4) Eskes, R., et al., Mol. Cell Biol. 20, 929-935 (2000) 5) Perez, D., et al., Mol. Cell Biol. 6, 53-63 (2000) 6) Zha, J., et al., Science 290, 1761-1765 (2000) 7) Korsmeyer, S.J., et al.,Cell Death Differ. 7,1166-1173 (2000) 8) Yin, X.M., et al., Nature 400, 886-891 (1999) 9) Luo, X., et al., Cell 94, 481-490 (1998) 10) Li, H., et al., Cell 94, 491-501 (1998) 11) Wang, K., et al., Genes. Dev. 10, 2859-2869 (1996)
Research Area Cell Death
Shipping Information 4°C
Size 100 µg
Source / Host mouse
Species Reactivity human
Stability 1 year
Storage -20°C
Substrate / Buffer 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
Technical Specifications Apoptosis is a major form of cell death characterized by several morphological features that include chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathway that leads to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-10 (also known as Mch4, FLICE2 and ICE-LAP4) is a ~58 kDa protein. This caspase acts upstream of the apoptosis induced cascade. Once this caspase is activated by certain apoptotic stimuli, this protein may be responsible for the activation of the other caspases such as caspase-3, -4, -7, -8, and -9. This antibody was made against human-originated immunogen, and detects human caspase-10 specifically.
Product Page Updated 2021-01-11T15:22:00.814Z

Shipping info

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