Article No
M072-3
Antibodies Primary
Anti-BID (Human) mAb
Anti-BID (Human) mAb
Product insert
Suggested protocols
Specifications
| Application | WB |
| Article No | M072-3 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL, RU |
| Clone | 5C9 |
| Clone Type | monoclonal |
| Concentration | 1 mg/mL |
| Description | Anti-BID (Human) mAb |
| Supplier | MBL International Corp. |
| Immunogen | Recombinant human Bid (61-118 a.a. end N) |
| Isotype | IgG1 |
| Notes | Apoptosis is a major form of cell death characterized by several morphological features that include chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathway that leads to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-10 (also known as Mch4, FLICE2 and ICE-LAP4) is a ~58 kDa protein. This caspase acts upstream of the apoptosis induced cascade. Once this caspase is activated by certain apoptotic stimuli, this protein may be responsible for the activation of the other caspases such as caspase-3, -4, -7, -8, and -9. This antibody was made against human-originated immunogen, and detects human caspase-10 specifically. |
| Product Type | Antibodies Primary |
| References | 1) Thiery, J., et al., J. Immunol. 174, 871-878 (2005) 2) Uddin, S., et al., Clin. Cancer Res. 11, 3102-3108 (2005) 3) Baumann, R., et al., FASEB J. 17, 2221-2230 (2003) 4) Eskes, R., et al., Mol. Cell Biol. 20, 929-935 (2000) 5) Perez, D., et al., Mol. Cell Biol. 6, 53-63 (2000) 6) Zha, J., et al., Science 290, 1761-1765 (2000) 7) Korsmeyer, S.J., et al.,Cell Death Differ. 7,1166-1173 (2000) 8) Yin, X.M., et al., Nature 400, 886-891 (1999) 9) Luo, X., et al., Cell 94, 481-490 (1998) 10) Li, H., et al., Cell 94, 491-501 (1998) 11) Wang, K., et al., Genes. Dev. 10, 2859-2869 (1996) |
| Research Area | Cell Death |
| Shipping Information | 4°C |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Stability | 1 year |
| Storage | -20°C |
| Substrate / Buffer | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained. |
| Technical Specifications | Apoptosis is a major form of cell death characterized by several morphological features that include chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathway that leads to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-10 (also known as Mch4, FLICE2 and ICE-LAP4) is a ~58 kDa protein. This caspase acts upstream of the apoptosis induced cascade. Once this caspase is activated by certain apoptotic stimuli, this protein may be responsible for the activation of the other caspases such as caspase-3, -4, -7, -8, and -9. This antibody was made against human-originated immunogen, and detects human caspase-10 specifically. |
| Product Page Updated | 2021-01-11T15:22:00.814Z |
Shipping info
The delivery time for this item is approximately 8-15 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.