Article No
M096-3
Anti-CD170 (Siglec-5) (Mouse) mAb
Anti-CD170 (Siglec-5) (Mouse) mAb
Antibodies Primary
Specifications
| Application | FC, IP |
| Article No | M096-3 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 8D2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/mL |
| Conjugation | Unconjugated |
| Description | Anti-CD170 (Siglec-5) (Mouse) mAb |
| Supplier | MBL |
| Immunogen | L cells transfected with mouse CD170 |
| Isotype | IgG2b |
| Notes | SiglecE (sialic acid-binding immunoglobulin-like lectin E/SigLec5/CD170) is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SiglecE is expressed on neutrophil and monocyte populations, both in the blood and bone marrow, as a dimeric, disulfide linked, 140 kDa type I membrane protein containing cytoplasmic immune receptor-based tyrosine signaling motifs. SiglecE recruits the SH2-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2, which block signal transduction through dephosphorylation of signaling molecules. Thus SiglecE acts as an inhibitory receptor for ligand induced tyrosine phosphorylation. |
| Product Type | Antibodies Primary |
| Shipping Information | 4°C |
| Size | 100 µg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Stability | 1 year |
| Storage | -20°C |
| Substrate / Buffer | 100 μg IgG in 100 μl PBS containing 50% glycerol, pH 7.2. Contains no preservatives. |
| Technical Specifications | SiglecE (sialic acid-binding immunoglobulin-like lectin E/SigLec5/CD170) is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SiglecE is expressed on neutrophil and monocyte populations, both in the blood and bone marrow, as a dimeric, disulfide linked, 140 kDa type I membrane protein containing cytoplasmic immune receptor-based tyrosine signaling motifs. SiglecE recruits the SH2-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2, which block signal transduction through dephosphorylation of signaling molecules. Thus SiglecE acts as an inhibitory receptor for ligand induced tyrosine phosphorylation. |
| Product Page Updated | 2023-12-29T16:20:16.638Z |
