Article No
MI-12-1
Application | FC, ICC, IP, WB |
Article No | MI-12-1 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 6F1 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Anti-EGF-R (Human) mAb |
Supplier | MBL |
Immunogen | Intracellular domain Recombinant human EGF-R (648-1186 aa) |
Isotype | IgG2b k |
Notes | The epidermal growth factor receptor (EGFR, ErbB-1) is a 170 kDa transmembrane glycoprotein that possesses intrinsic tyrosine kinase activity. There are several EGF family ligands including epidermal growth factor (EGF), amphiregulin (AR), heparin-binding epidermal growth factor (HB-EGF), epiregulin, betacellulin, transforming growth factor-α (TGF-α) and epigen, which can bind and activate the EGFR. Ligand binding facilitates dimerization of the EGFR, which activates downstream pathways known to be involved in cell growth, proliferation, differentiation and migration. Other members of the receptor tyrosine kinase family, which include EGFR, ErbB-2/HER-2, ErbB-3/HER-3 and ErbB-4/HER-4, are also known to play important roles in regulating a wide variety of cellular functions. Overexpression by gene amplification or mutation of these receptors correlates with the development and progression of several human cancers, as well as poor prognosis. Consequently, these receptors have been identified not only as a possible prognostic markers but also primarily a rational molecular target for an anticancer agents. |
Product Type | Antibodies Primary |
Research Area | Immunology |
Shipping Information | 4°C |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human |
Stability | 1 year |
Storage | -20°C |
Substrate / Buffer | The protein concentration should be 1 mg/mL and the IgG concentration should be 100 μg/mL in PBS 50% glycerol, pH 7.2. No preservatives are contained. |
Technical Specifications | The epidermal growth factor receptor (EGFR, ErbB-1) is a 170 kDa transmembrane glycoprotein that possesses intrinsic tyrosine kinase activity. There are several EGF family ligands including epidermal growth factor (EGF), amphiregulin (AR), heparin-binding epidermal growth factor (HB-EGF), epiregulin, betacellulin, transforming growth factor-α (TGF-α) and epigen, which can bind and activate the EGFR. Ligand binding facilitates dimerization of the EGFR, which activates downstream pathways known to be involved in cell growth, proliferation, differentiation and migration. Other members of the receptor tyrosine kinase family, which include EGFR, ErbB-2/HER-2, ErbB-3/HER-3 and ErbB-4/HER-4, are also known to play important roles in regulating a wide variety of cellular functions. Overexpression by gene amplification or mutation of these receptors correlates with the development and progression of several human cancers, as well as poor prognosis. Consequently, these receptors have been identified not only as a possible prognostic markers but also primarily a rational molecular target for an anticancer agents. |
Product Page Updated | 2023-12-29T16:20:16.638Z |