Article No
MONX10872
Mouse anti-Beta-Catenin, clone 17C2
Mouse anti-Beta-Catenin, clone 17C2
Antibodies Primary
Specifications
| Additional Information | The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer. |
| Application | IHC |
| Article No | MONX10872 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 17C2 |
| Clone Type | monoclonal |
| Concentration | Greater than or equal to 51 mg/L |
| Conjugation | Unconjugated |
| Description | Mouse anti-Beta-Catenin, clone 17C2 |
| Supplier | SANBIO bv/Monosan |
| Format | - |
| Immunogen | Prokaryotic recombinant protein corresponding to a 160 amino acid region of the C-terminus of the beta-catenin molecule. |
| Isotype | IgG2a |
| Notes | The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer. |
| Product Type | Antibodies Primary |
| Protocol | IHC-P (1:150) |
| Shipping Information | blue ice |
| Size | 1 ml |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 2-8°C |
| Substrate / Buffer | Tissue culture supernatant with sodium azide |
| Product Page Updated | 2024-01-12T18:37:31.725Z |
