Article No
PD011
Anti-ATBF1 (AT-6) (Human) pAb
Anti-ATBF1 (AT-6) (Human) pAb
Antibodies Primary
Specifications
| Application | IP, WB |
| Article No | PD011 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | Anti-ATBF1 (AT-6) (Human) pAb |
| Supplier | MBL |
| Immunogen | C-terminal region of mouse ATBF1 (3405-3549 aa) |
| Isotype | Ig |
| Notes | ATBF1 (also known as ZFHX3) is a transcription factor that has two-protein isoforms, the 404 kDa ATBF1-A and the 306 kDa ATBF1-B. ATBF1-A contains four homeodomains and 23 zinc-finger motifs. ATBF1-B contains four homeodomains and 18 zinc fingers. ATBF1 is identified as DNA-binding protein, which binds to an AT-rich element of the human α-fetoprotein (AFP) gene, as a result suppressing its transcription activity. ATBF1 is also involved in cell cycle arrest and cooperating with p53 to activate the p21Waf1/Cip1 promoter. ATBF1 is expressed in the differentiation fields in association with β-tubulin III and MAP2 that are the neuronal differentiation marker. ATBF1 plays a crucial role in neuronal development and cell cycle arrest. |
| Product Type | Antibodies Primary |
| Shipping Information | 4°C |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | human, mouse, rat |
| Stability | 1 year |
| Storage | -20°C |
| Substrate / Buffer | 100 μl volume of PBS containing 50% glycerol, pH 7.2. Contains no preservative. |
| Technical Specifications | ATBF1 (also known as ZFHX3) is a transcription factor that has two-protein isoforms, the 404 kDa ATBF1-A and the 306 kDa ATBF1-B. ATBF1-A contains four homeodomains and 23 zinc-finger motifs. ATBF1-B contains four homeodomains and 18 zinc fingers. ATBF1 is identified as DNA-binding protein, which binds to an AT-rich element of the human α-fetoprotein (AFP) gene, as a result suppressing its transcription activity. ATBF1 is also involved in cell cycle arrest and cooperating with p53 to activate the p21Waf1/Cip1 promoter. ATBF1 is expressed in the differentiation fields in association with β-tubulin III and MAP2 that are the neuronal differentiation marker. ATBF1 plays a crucial role in neuronal development and cell cycle arrest. |
| Product Page Updated | 2023-12-29T16:20:16.638Z |
