Article No
PM036
Application | FC, ICC, IHC, IP, WB |
Article No | PM036 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | Anti-LC3 (Human) pAb |
Supplier | MBL |
Immunogen | Recombinant human LC3 (MAP1LC3B :1-120 a.a.) |
Isotype | IgG |
Notes | Macroautophagy mediates the bulk degradation of cytoplasmic components. These components are delivered to lysosomes via autophagosomes. The microtubule-associated protein 1 light chain 3 (LC3), a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I (18 kDa). A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II (16 kDa). This antibody can detect both forms of LC3. |
Product Type | Antibodies Primary |
Research area | Cell Death |
Shipping Information | 4°C |
Size | 100 µl |
Source / Host | rabbit |
Species Reactivity | human, mouse, rat, hamster |
Stability | 1 year |
Storage | -20°C |
Substrate / Buffer | 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
Technical Specifications | Macroautophagy mediates the bulk degradation of cytoplasmic components. These components are delivered to lysosomes via autophagosomes. The microtubule-associated protein 1 light chain 3 (LC3), a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I (18 kDa). A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II (16 kDa). This antibody can detect both forms of LC3. |
Product Page Updated | 2023-12-29T16:20:16.638Z |