Article No
PM077
Application | IP, WB |
Article No | PM077 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | Anti-5-hydroxymethylcytosine (5hmC) pAb |
Supplier | MBL |
Immunogen | BSA-conjugated 5-hydroxymethylcytidine |
Isotype | Ig |
Notes | DNA methylation is one of many critical epigenetic modifications. In most cases, cytosine (C) in DNA sequence is converted to 5-methylcytosine (5mC) with addition of a methyl group by the enzymatic activity of DNA methyltransferase. DNA methylation plays a role in the regulation of gene expression. It has been reported that abnormal DNA methylation level is involved in many diseases. 5-hydroxymethylcytosine (5hmC), a newly identified epigenetic modification following 5mC, is generated from oxidation of 5mC by the enzymatic activity of TET family proteins. 5hmC may function as a regulator of gene expression as well as 5mC. |
Product Type | Antibodies Primary |
Research Area | Epigenetics |
Shipping Information | 4°C |
Size | 100 µl |
Source / Host | rabbit |
Storage | -20°C |
Substrate / Buffer | PBS/50% glycerol, pH 7.2 |
Technical Specifications | DNA methylation is one of many critical epigenetic modifications. In most cases, cytosine (C) in DNA sequence is converted to 5-methylcytosine (5mC) with addition of a methyl group by the enzymatic activity of DNA methyltransferase. DNA methylation plays a role in the regulation of gene expression. It has been reported that abnormal DNA methylation level is involved in many diseases. 5-hydroxymethylcytosine (5hmC), a newly identified epigenetic modification following 5mC, is generated from oxidation of 5mC by the enzymatic activity of TET family proteins. 5hmC may function as a regulator of gene expression as well as 5mC. |
Product Page Updated | 2023-12-29T16:20:16.638Z |