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|Country Availability||DK, EE, FI, FO, GL, IS, LT, LV, NO, SE|
|Data Sheet Link||https://www.mblintl.com/assets/rn0019m-v1.pdf|
|Description||Anti-2,2,7-trimethylguanosine (m3G/TMG) mAb|
|Supplier||MBL International Corp.|
|Notes||Small nuclear RNA (snRNA) is known to be involved in pre-mRNA splicing as an RNA component of snRNP. 2,2,7-trimethylated guanosine (m3G/TMG) is a modified nucleoside at the 5’-cap site of U snRNAs except for U6 snRNA. Shortly after transcription, 7-methylguanosine (m7G), called cap structure, is added to 5’-end of <a>newly</a> synthesized U snRNA and m7G-capped U snRNA is exported to the cytoplasm. The m7G-cap is converted to m3G-cap, which is a hypermethylated structure of 5’-end, by cytoplasmic catalytic protein TSG1 and the m3G-capped U snRNA forms snRNP with Sm proteins in the cytoplasm, followed by entry into the nucleus. The m3G-capped snRNP plays a role in regulation of pre-mRNA splicing as a part of spliceosome in nucleus. <a>It is also reported that</a> U3 and U8 snoRNA, localized to Cajal body during RNP biogenesis, possess m3G-cap structure.|
|Alias Names||N2,N2,7-Trimethylguanosine, m2,2,7G|
|Source / Host||mouse|
|Substrate / Buffer||1 mg/mL in PBS/50% glycerol, pH 7.2|
|Product Page Updated||2019-01-15T09:09:13.918Z|
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