Article No
SBB-PS0043-C050
Ubiquitin-AMC (human) (rec.) (untagged)
Ubiquitin-AMC (human) (rec.) (untagged)
Proteins & Peptides
Specifications
| MW | ~8.7kDa |
| Article No | SBB-PS0043-C050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Concentration | Lot dependent. |
| Conjugation | AMCA |
| Description | Ubiquitin-AMC (human) (rec.) (untagged) |
| Supplier | Adipogen Life Sciences |
| Entrez Gene ID | 7314 |
| Gene Symbol | UBB |
| Notes | Recombinant Protein. Full-length, mature ubiquitin polypeptide (amino acids 1-76) conjugated on its C-terminus to AMC. Source/Host: E. coli. Liquid. In 50mM MES pH 6.0. Ubiquitin is a 76 amino acid post-translational modifier expressed throughout all tissues in eukaryotic organisms. The many roles of ubiquitin modification include proteasomal degradation, signal transduction, inflammatory response, and DNA damage repair. Ubiquitin modification occurs through a pyramidal cascade of an E1 activating enzyme, E2 conjugating enzymes, and an E3 ubiquitin ligases. This enzymatic cascade results in modification of a epsilon-amine of a lysine residue on a substrate protein. Substrates may either be mono or poly-ubiquitinated by M1, K6, 11, 27, 29, 33, 48 or 63 linkages. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various specificities.|Ubiquitin is a 76 amino acid post-translational modifier expressed throughout all tissues in eukaryotic organisms. The many roles of ubiquitin modification include proteasomal degradation, signal transduction, inflammatory response, and DNA damage repair. Ubiquitin modification occurs through a pyramidal cascade of an E1 activating enzyme, E2 conjugating enzymes, and an E3 ubiquitin ligases. This enzymatic cascade results in modification of a epsilon-amine of a lysine residue on a substrate protein. Substrates may either be mono or poly-ubiquitinated by M1, K6, 11, 27, 29, 33, 48 or 63 linkages. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various specificities. |
| Alias Names | Ub-AMC; Ub-7-Amido-4-methylcoumarin |
| Product Type | Proteins & Peptides |
| Purity | >99% |
| Sequence | Full-length, mature ubiquitin polypeptide (amino acids 1-76) (Accession Nr. P0CG47 http://www.ncbi.nlm.nih.gov/protein/P0CG47 ) conjugated on its C-terminus to AMC. |
| Shipping Information | DRY ICE |
| Size | 50 µg |
| Species Reactivity | human |
| Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Storage | -80°C |
| Substrate / Buffer | Liquid. In 50mM MES pH 6.0. |
| Technical Specifications | Recombinant Protein. Full-length, mature ubiquitin polypeptide (amino acids 1-76) conjugated on its C-terminus to AMC. Source/Host: E. coli. Liquid. In 50mM MES pH 6.0. Ubiquitin is a 76 amino acid post-translational modifier expressed throughout all tissues in eukaryotic organisms. The many roles of ubiquitin modification include proteasomal degradation, signal transduction, inflammatory response, and DNA damage repair. Ubiquitin modification occurs through a pyramidal cascade of an E1 activating enzyme, E2 conjugating enzymes, and an E3 ubiquitin ligases. This enzymatic cascade results in modification of a epsilon-amine of a lysine residue on a substrate protein. Substrates may either be mono or poly-ubiquitinated by M1, K6, 11, 27, 29, 33, 48 or 63 linkages. Removal of ubiquitin from a substrate protein occurs via deconjugating enzymes, of which there are nearly 100 known enzymes with various specificities. |
| UniProt Number | P0CG47 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
