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6-Aminophenanthridine

Chemicals & Biochemicals

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Article No

AG-MR-C0029-M005

Size

5 mg

Shipping Information

Article No

AG-MR-C0029-M005

Size

5 mg

Specifications

CAS No	832-68-8
MW	194.2
Article No	AG-MR-C0029-M005
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	6-Aminophenanthridine
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Antiprion agent. Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.\|Chemical. CAS: 832-68-8. Formula: C13H10N2. MW: 194.2. Antiprion agent. Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.
Molecular Formula	C13H10N2
Alias Names	6AP
Product Type	Chemicals & Biochemicals
Purity	>97%
Research area	Cell Death
Shipping Information	RT
Size	5 mg
Solubility	Soluble in DMSO or ethanol.
Stability	Stable for at least 2 years after receipt when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 832-68-8. Formula: C13H10N2. MW: 194.2. Antiprion agent. Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

An expeditious synthesis of 6-aminophenanthridines: F. Gug, et al.; THL 46, 3725 (2005) | Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs: D. Tribouillard-Tanvier, et al.; PLoS One 3, e2174 (2008) | Tools for the study of ribosome-borne protein folding activity: C. Voisset, et al.; Biotechnol. J. 3, 1033 (2008) | Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding: S.D. Reis, et al.; Biochimie 93, 1047 (2011) | Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy: N. Barbezier, et al.; EMBO Mol. Med. 3, 35 (2011) | The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition: Y. Pang, et al.; J. Biol. Chem. 288, 19081 (2013)

Shipping info

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